Anderlecht (Belgium) – Manchester United (England)
Journey to the quarter final:
Anderlecht (Group C runner-up) – vs Saint-Etienne (3-4), vs Mainz 05 (7-2), vs Gabala (6-2), vs Zenit Saint Petersburg (3-3); away goals, vs APOEL (2-0)
Manchester United (Group A runner-up) – vs Fenerbahce (5-3), vs Feyenoord (4-1), vs Zorya (3-0), vs Saint-Etienne (4-0), vs Rostov (2-1)
Celta Vigo (Spain) – Genk (Belgium)
Journey to the quarter final:
Celta Vigo (Group G runner-up) – vs Ajax (4-5), vs Standard Liege (2-2), vs Panathinaikos (4-0), vs Shakhtar Donetsk (2-1), vs Krasnodar (4-1)
Genk (Group F winner) – vs Athletic Club (5-5);away goals, vs Rapid Wien (3-3);away goals, vs Sassuolo (5-1), vs Astra (3-2), vs Gent (6-3)
Ajax (Netherlands) – Schalke 04 (Germany)
Journey to the quarter final:
Ajax (Group G winner) – vs Celta Vigo (5-4), vs Standard Liege (2-1), vs Panathinaikos (4-1), vs Legia Warsaw (1-0), vs Copenhagen (3-2)
Schalke 04 (Group I winner) – vs Krasnodar (3-0), vs RB Salzburg (3-3), vs OGC Nice (3-0), vs PAOK (4-1), Borussia Mönchengladbach (3-3) on away goals.
Lyon (France) – Besiktas (Turkey)
Journey to the quarter final:
Lyon (relegated from the UEFA Champions League) – vs Juventus (1-2), vs Sevilla (0-1), vs Dinamo Zagreb (4-0), vs AZ Alkmaar (11-2), vs Roma (5-4)
Besiktas (relegated from the UEFA Champions League) – vs Nap